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After looking into it a bit, I would feel more confident applying Nerium-AD than I would having Botox injections.
I'd like to point out that botulism is an extremely deadly neurotoxin in extremely small doses, but people have Botox injections regularly.I am not a doctor. Based on results, N. oleander was found to be both nephrotoxic and hepatotoxic.This information relates to an herbal, vitamin, mineral or other dietary supplement. So, there is a new anti-aging cream called Nerium-AD which contains nerium oleander. Signs of an allergic skin reaction to oleander include itching, hives, redness, and inflammation.
After NOLE treatment, additional promising results included normalization of HbAAn extract of N. oleander administered to rats via intragastric route resulted in dose-dependent reductions in total cholesterol, TG, LDL, and very low–density lipoprotein levels.
It is important to note, however, that there is no safe dosage for this substance, because diluted or not, the parts of this plant are extremely toxic. Signs of toxicity include severe nausea, emesis, abdominal pain, cramping, diarrhea, hyperkalemia, hypertension, lethargy, hepatotoxicity, and nephrotoxicity. Oleander was detected in the urine at a concentration of 3.2 ng/mL and in the serum at a concentration of 8.4 ng/mL.A 33-year-old woman who ingested 25 g of N. oleander leaves boiled in 350 mL of water for 20 minutes developed headache, vomiting, bradycardia, and hyperkalemia.
Examination also showed sinus bradycardia, increased blood pressure, and hyperkalemia. The red, pink, or white fluffy flowers form in small clusters. Extensive iron accumulation was found in the liver.
With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Postingestion, clinical signs of toxicosis can be seen within 2 hours, but might not appear for up to 48 hours depending on the type ingested.In birds, as little as 0.12 to 0.7 g of the plant has caused death.Common blood chemistry changes associated with oleander toxicosis include azotemia, hyperglycemia, elevated creatine phosphokinase and lactate levels, and hyperkalemia.Oleander toxicity should be managed aggressively.
Oleander is native to Africa, Europe, North America, and the Mediterranean.Oleander was used by primitive people as arrow and dart poisons.The oleander plant contains a number of related cardiac glycosides similar in activity to digitalis. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. Nerium Oleander is a shrub.
NOLE administered to mice orally for 20 days resulted in substantial decreases in liver marker enzymes, as well as in cholesterol and TG levels. Upon discharge from treatment, one developed persistent atrial fibrillation.In a case report, a 1-year-old miniature horse experiencing lethargy and inappetence for 12 hours was taken to a veterinarian and treated for symptoms and arrhythmias, with no improvement after 24 hours. Euglycemia was achieved after dextrose bolus.In a retrospective study with 8 camelids, 3 were treated for oleander toxicity, one resulting in death. Cellular disruption and degeneration of white pulp was noted in the spleen, possibly due to immunotoxic effects of xenobiotics of their metabolites in the extract of the leaves. After 6 weeks of treatment at the highest dose (40 mg/kg), PBI-05204 nearly eradicated tumor growth.Screening studies of cardenolide compounds extracted from oleander plants suggest anticancer activity.An aqueous extract containing the cardiac glycosides oleandrin, odorside, and neritaloside, and the aglycone oleandrigenin (Anvirzel) has been studied in a phase 1 clinical trial in 18 patients with advanced, refractory solid tumors. Even though it is toxic, people still use nerium oleander to treat cancers, such as those of the prostate, lung, and bladder.Skin irritation from nerium oleander and allergic reactions are also possible.
Dermatitis may result when crushed leaves of the shrub come into contact with the skin of an individual with sensitivity to a prior exposure. A second horse from the same farm experienced lethargy and anorexia for 6 hours, with further deterioration 12 hours later.
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